Apoptosis‐induced T‐cell lymphopenia is related to COVID‐19 severity

Increased levels of acute-phase reactants and lymphopenia are predictors disease severity in coronavirus 2019 (COVID-19). This study aimed to investigate the role apoptosis etiology patients with COVID-19. multicentered, prospective, case-control was conducted polymerase chain reaction (+) severe acute respiratory syndrome 2 (SARS-CoV-2) patients, an age–gender-matched control group. Samples were taken at time diagnosis analyzed via flow cytometry within 24 h. The participants' demographic data initial laboratory tests also recorded. In total, 33 COVID-19 (mean age = 45.4 ± 17.2) 25 controls 43.4 17.4) participated study. All identified as having mild (16), moderate (5), or (12) severity. Both early late apoptotic cells B T lymphocytes increased all (p < .05). Early (EA) higher cases compared .026). There no significant difference between However, (n 14) .013) had EA lymphocytes. study's results show that lymphocytes' increases addition, enhanced lymphocyte is associated lymphopenic